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KMID : 0878220120240030080
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Journal of Sasang Constitutional Medicine
2012 Volume.24 No. 3 p.80 ~ p.92
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Effects of Korean Herbal Bathing Extracts Composition on Th2 Cytokine Production in MC/9 Mast Cells
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Jang Moon-Hee
Choi Jae-Song
Choi Ae-Ryun
Ahn Taek-Won
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Abstract
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Objectives: The purpose of this study is to investigate the effects of korean herbal bathing extracts composition 1 and composition 2 on Th2 cytokine production in MC/9 mast cells.
Methods: The effects of composition 1, 2 was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13
were analyzed with Real-time PCR.
Results: Composition 1, 2 inhibited the IL-5, IL-13 production signifcantly(p<.001) in comparison to PI-control group at concentration of 100 ㎍/mL, 200 ㎍/mL. Composition 1, 2 inhibited the IL-4, IL-5, IL-13 mRNA expression signifcantly in comparison to PI-control group at concentration of 100 ㎍/mL, 200 ㎍/mL. Composition 1 inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of 200 ㎍/㎖. Composition 2 inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of 100 ㎍/mL, 200 ㎍/mL.
Conclusions: These results indicate that composition 1, 2 has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.
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KEYWORD
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Korean Herbal Bathing Extracts Composition, Cytokine, MC/9 Mast Cell, Atopic Dermatitis
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